产品编号：C380980

产品规格：500mg

产品价格：面议

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产品详情

标准品编号:	C380980
名称:	1-[[5-(4-Chlorophenyl)furan-2-yl]methylideneamino]imidazolidine-2,4-dione
别名:	1-[[5-(p-Chlorophenyl)furfurylidene]amino]-hydantoin; F 410;
CAS号:	14663-26-4
分子式:	C₁₄H₁₀ClN₃O₃
分子量:	303.7
类别:	Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	1-[[5-(4-Chlorophenyl)furan-2-yl]methylideneamino]imidazolidine-2,4-dione is an intermediate of Azimilide Dihydrochloride(A926950), which is an oral type III potassium channel blocker agent that blocks both the rapid activating component and the slow activating component of the delayed rectifier potassium current. Both preclinical and clinical studies have demonstrated the efficacy of azimilide and its safety in the treatment of supraventricular and ventricular tachyarrhythmia. Azimilide also is being studied in a worldwide multicenter trial for prevention of sudden cardiac death in patients after myocardial infarction.
参考文献	Tran, H.T., et al.: Heart. Dis., 1, 114 (1999); Conway, E., et al.: Am. J. Cardiol., 102, 12 (2008); Carlson, M., et al.: Exp. Rev. Cardio. Therap., 3, 387 (2005); Dorian, P., et al.: J. Cardio. Pharm. Therap., 7, 211 (2002);