产品编号：C374760
产品规格：5mg
产品价格：面议
| 标准品编号: | C374760 |
| 名称: | 2-Chloro-5-nitro-N-4-pyridinylbenzamide |
| 别名: | T0070907 |
| CAS号: | 313516-66-4 |
| 分子式: | C₁₂H₈ClN₃O₃ |
| 外观: | Light Beige to Light Brown Solid |
| 熔点: | >184°C (dec.) |
| 分子量: | 277.66 |
| 储存: | 冰箱保存 |
| 溶解度: | DMSO (Slightly), Methanol (Slightly) |
| 类别: | Standards; Enzyme Activators and Inhibitors; |
| 应用: | A cell-permeable chloro-nitro-benzamido compound that acts as a potent, specific, irreversible, and high-affinity antagonist of PPARγ with a Ki of 1 nM. Displays >800-fold greater selectivity for PPARγ over PPARα and PPARδ (Ki = 0.85 µM and 1.8 µM, respectively). Blocks hormone- and agonist-induced adipogenesis in 3T3-L1 cells. It suppresses interactions between PPARγ and coactivator-derived peptides, while promotes the recruitment of corepressor-derived peptides. Shown to modulate the interaction of PPARγ2 with the cofactor proteins through covalent binding to Cys313 in its ligand-binding domain. |
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