产品编号：C370145

产品规格：25mg

产品价格：面议

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产品详情

标准品编号:	C370145
名称:	Chloromethyl (S,R)-Palonosetron Chloride
别名:	(1R,3R,4R)-1-(Chloromethyl)-3-((S)-1-oxo-3a,4,5,6-tetrahydro-1H-benzo[de]isoquinolin-2(3H)-yl)quinuclidin-1-ium Chloride
分子式:	C₂₀H₂₆ClN₂O⁺ • Cl ⁻
外观:	白色固体
分子量:	345.893545
类别:	Standards; Chiral Molecules; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	Chloromethyl (S,R)-Palonosetron Chloride is a by-product during the synthesis of (S,R)-Palonosetron Hydrochloride (P165810), (S,R)-enantiomer of Palonosetron (P165800), which is a potent and selective antagonist, with 5-HT3 receptor in vitro. An impurity of Palonosetron.
参考文献	Clark, R.D., et al.: J. Med. Chem., 36, 2645 (1993); Wong, E.H.F., et al.: Br. J. Pharmacol., 114, 851 (1995); Grunberg, S.M., et al.: Expert. Opin. Pharmacother., 4, 2297 (2003); Eisenberg, P., et al.: Ann. Oncol., 15, 330 (2004); Siddiqui, M.A.A., et al.: Drugs, 64, 1125 (2004)