产品编号：C365781
产品规格：5mg
产品价格：面议
| 标准品编号: | C365781 |
| 名称: | (Z)-Chlorolefin-13C6 |
| 别名: | (Z)-1-[4-(2-Chloroethoxyphenyl]-1,2-diphenyl-1-butene-13C6 |
| 参考CAS: | 97818-83-2 |
| 分子式: | C₁₈¹³C₆H₂₃ClO |
| 外观: | 白色固体 |
| 分子量: | 368.85 |
| 储存: | -20°C Freezer |
| 溶解度: | Chloroform; Dichloromethane |
| 类别: | Standards; Isotopic Labeled Analogues; Pharmaceutical/API Drug Impurities/Metabolites; |
| 应用: | (Z)-Chlorolefin-13C6 is an intermediate in the synthesis of Tamoxifen-13C6 (T006002), which is a labeled Tamoxifen; a selective estrogen response modifier (SERM), protein kinase C inhibitor and anti-angiogenetic factor. Tamoxifen is a prodrug that is metabolized to active metabolites 4-hydroxytamoxifen (4-OHT) and endoxifen by cytochrome P450 isoforms CYP2D6 and CYP3A4. In breast cancer, the gene repressor activity of tamoxifen against ERBB2 is dependent upon PAX2. Blocks estradiol-stimulated VEGF production in breast tumor cells. Protein kinase C inhibitor. Induces apoptosis in human malignant glioma cell lines. Tamoxifen and its metabolite 4-hydroxytamoxifen (H954725) are selective estrogen response modifiers (SERMs) that act as estrogen antagonists in mammary gland. Blocks estradiol-sti |
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