产品编号：C364966

产品规格：50mg

产品价格：面议

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产品详情

标准品编号:	C364966
名称:	2-Chloro-N-[4-(1-cyanocyclopentyl)phenyl]-3-pyridinecarboxamide-d8
参考CAS:	1158560-99-6
分子式:	C₁₈H₈D₈ClN₃O
分子量:	333.84
类别:	Standards; Isotopic Labeled Analogues; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	2-Chloro-N-[4-(1-cyanocyclopentyl)phenyl]-3-pyridinecarboxamide-d8 is an intermediate used in the synthesis of Apatinib-d8 Hydrochloride (A726152), which is a labelled Apatinib (A726150). Apatinib is an orally available, small molecule multitargeted tyrosine kinase inhibitor. Apatinib selectively inhibits the vascular endothelial growth factor receptor-2 (VEGFR2). Apatinib functions by inhibiting VEGF-mediated endothelial cell migration and proliferation thus blocking new blood vessel formation in tumor tissue. Recent studies have shown that Apatinib enhances the efficacy of conventional chemotherapeutical drugs in side population (SP) cells and ABCB1-overexpressing leukemia cells.
参考文献	Mi, Y. et al.: Cancer Res., 70, 7981 (2010); Tong, X.Z. et al.: Biochem. Pharmacol., 83, 586 (2012); Ding, J, et al.: J. Chrom B Anal. Technol. Biomed. Life Sci., 895, 108 (2012);