产品编号：C177840

产品规格：100mg

产品价格：面议

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产品详情

标准品编号:	C177840
名称:	m-Carboxycinnamic Acid Bishydroxamide
别名:	N-Hydroxy-3-[3-(hydroxyamino)-3-oxo-1-propen-1-yl]benzamide; CBHA;
CAS号:	174664-65-4
分子式:	C₁₀H₁₀N₂O₄
分子量:	222.2
类别:	Research Tools;
应用:	Histone deacetylase inhibitor II. A cell-permeable second generation hybrid polar agent that inhibits HDAC activity. Inhibition is believed to arise as a result of the binding of the hydroxamic moiety to the active site zinc. Induces apoptosis and Fas/Fas ligand expression in human neuroblastoma.
参考文献	Yoshida, M., et al.: J. Biol. Chem., 265, 17174 (1990), Lee, B., et al.: Cancer Res., 61, 931 (2001), Takai, N., et al.: Clin. Cancer Res., 10, 1141 (2004), Ryan, Q., et al.: J. Clin. Oncol., 23, 3912 (2005), Rahnama, F., et al.: Endocrinology, 147, 5275 (2006),