产品编号：C176395

产品规格：2.5mg

产品价格：面议

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产品详情

标准品编号:	C176395
名称:	22-Carboxy Vitamin D3
别名:	(9CI)[1R-[1α(S*),3aβ,4E[Z(S*)],7aα]]-Octahydro-4-[(5-hydroxy-2-methylenecyclohexylidene)ethylidene]-α,7a-dimethyl-1H-indene-1-acetic acid
CAS号:	99518-38-4
分子式:	C₂₂H₃₂O₃
分子量:	344.49
类别:	Standards; Vitamin Derivatives; Vitamin D Derivatives;
应用:	22-Carboxy Vitamin D3 is an analogue of Vitamin D3 (V676045), which is fat-soluable vitamin that mediates intestinal calcium absorbtion, and bone calcium metabolism. Vitamin D acts through a receptor that is a member of the ligand-dependent transcription factor superfamily. It modulates the proliferation and differentiation of both normal and cancer cells. It also has antiproliferative and antimetastatic effects on breast, colon, and prostate cancer cells. Activated vitamin D receptors in intestine and bone maintain calcium absorbance and homeostasis.
参考文献	Haussler, R., et al.: J. Biol. Chem., 247, 2328 (1972); Holick, M.F., Rec. Res. Canc. Res., 164, 3 (2003); Palmer, H.G., et al.: Cancer Res., 63, 7799 (2003); Welsh, J., et al.: J. Nutr., 133, 2425S (2003); Huhtakangas, J., et al.: Mol. Endocrinol., 18, 2660 (2004);