产品编号：C175147

产品规格：5mg

产品价格：面议

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产品详情

标准品编号:	C175147
名称:	(R)-(-)-Camptothecin-d5
别名:	R)-4-(Ethyl-d5)-4-hydroxy-1H-pyrano[3’,4’:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; (R)-(-)-Camptothecine-d5; (R)-Camptothecin-d5; 20R-Camptothecin-d5;
CAS号:	1329793-44-3
参考CAS:	110351-92-3-未标记
分子式:	C₂₀H₁₁D₅N₂O₄
分子量:	353.38
类别:	Standards; Isotopic Labeled Analogues; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	Labelled (R)-(-)-Camptothecin (C175145). Antitumor alkaloid. Binds irreversible to the DNVIP(LA)topoisomerase I complex, inhibiting the reassociation of DNA after cleavage by topoisomerase I and traps the enzyme in a covalent linkage with DNA. A cytotoxic antitumor agent.
参考文献	Potmesil, M., et al.: Cancer Res., 54, 1431 (1994), Desai, S.D., et al.: J. Biol. Chem., 272, 24159 (1997), Fan, Y., et al.: J. Med. Chem., 41, 2216 (1998), Kaufmann, S.H., et al.: Biochim. Biophys. Acta, 1400, 195 (1998),