产品编号：B812310
产品规格：50mg
产品价格：面议
| 标准品编号: | B812310 |
| 名称: | N'-(4-Butyl-2-methylphenyl)-N,N-dimethyl-methanimidamide |
| 别名: | N'-(4-Butyl-2-methylphenyl)-N,N-dimethylformimidamide |
| CAS号: | 398144-05-3 |
| 分子式: | C₁₄H₂₂N₂ |
| 分子量: | 218.34 |
| 类别: | Building Blocks; Miscellaneous; |
| 应用: | N'-(4-Butyl-2-methylphenyl)-N,N-dimethyl-methanimidamide is an intermediate in the synthesis of N-Hydroxy-N’-(4-butyl-2-methylphenyl)formamidine (H831225), which is a potent and selective inhibitor of the biosynthesis of 20-HETE acting via inhibition of CYP4A (IC50=8.9nM (human), 35nM (rat renal microsome). IC50 cyclooxygenase=2.3uM. IC50 for other CYP’s: CYP2C9-3.3uM, CYP2D6=83.9 uM, CYP3A4=71uM. It inhibits cerebrovascular constriction induced by Ca2+ or archidonate and inhibits angiogenesis and endothelial cell sprouting in various models. Displays protective effect on brain damage after temporary focal ischemia (at 10mg/Kg). |
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