产品编号：B807080

产品规格：250mg

产品价格：面议

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产品详情

标准品编号:	B807080
名称:	tert-​Butyl 6-​Cyano-​2-​(2-​(4-​ethyl-​3-​iodophenyl)​propan-​2-​yl)​-​1H-​indole-​3-​carboxylate
CAS号:	1256584-75-4
分子式:	C₂₅H₂₇IN₂O₂
分子量:	514.4
类别:	Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	tert-​Butyl 6-​Cyano-​2-​(2-​(4-​ethyl-​3-​iodophenyl)​propan-​2-​yl)​-​1H-​indole-​3-​carboxylate is an intermediate of Alectinib (C183360), a highly selective and potent anaplastic lymphoma kinase (ALK) inhibitor capable of blocking the resistant gatekeeper mutant, which results in reduced cell growth.
参考文献	Jiang, X. et al.: Eur. J. Med. Chem., 105, 39 (2015); Sakamoto, H., et al.: Cancer Cell., 19, 679 (2011); Kinoshita, K., et al.: Bio-org. Medn., 20, 1271 (2012);