产品编号：B694175

产品规格：25mg

产品价格：面议

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产品详情

标准品编号:	B694175
名称:	(2-((1R,3S,4S)-2-(tert-butoxycarbonyl)-2-azabicyclo[2.2.1]heptan-3-yl)-1H-benzo[d]imidazol-5-yl)boronic Acid
分子式:	C₁₈H₂₄BN₃O₄
分子量:	357.21
类别:	Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	(2-((1R,3S,4S)-2-(tert-butoxycarbonyl)-2-azabicyclo[2.2.1]heptan-3-yl)-1H-benzo[d]imidazol-5-yl)boronic Acid can be obtained from (1R,3S,4S)-2-(tert-Butoxycarbonyl)-2-azabicyclo[2.2.1]heptane-3-carboxylic Acid (B694100) which is a building block in the synthesis of Ledipasvir, a potent, once-​daily oral NS5A inhibitor for the treatment of Hepatitis C Virus infection. It is also used to prepare potent direct inhibitors of factor Xa which carries significant promise for developing effective and safe anticoagulants.
参考文献	Link, J., et al.: J. Med. Chem., 57, 2033(2014); Al-Hornai, R;, et al.:Eur. J. Med. Chem., 54, 771 (2012)