产品编号：B691475

产品规格：10mg

产品价格：面议

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产品详情

标准品编号:	B691475
名称:	42-O-tert-Butyldimethylsilyloxyethyl Rapamycin
别名:	42-O-[2-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]ethyl]rapamycin; 23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine Rapamycin Deriv.; Everolimus tert-Butyldimethylsilyl Ether
CAS号:	159351-68-5
分子式:	C₅₉H₉₇NO₁₄Si
外观:	白色至白色固体
熔点:	>93°C (dec.)
分子量:	1072.49
储存:	Hygroscopic, -20°C Freezer, Under inert atmosphere
溶解度:	Chloroform (Slightly), Methanol (Slightly)
稳定性:	Hygroscopic
类别:	Standards; Chiral Molecules; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	42-O-tert-Butyldimethylsilyloxyethyl Rapamycin is a useful synthetic intermediate in the synthesis of Everolimus (E945400); an immunosuppressant macrolide and analog of the parent drug Rapamycin (R124000). Everolimus inhibits cytokine-mediated lymphocyte proliferation.
参考文献	Dumont, F.J., et al.: Curr. Opin. Invest. Drugs, 2, 1220 (2001); Kovarik, J. M., et al.: Clin. Pharmacol. Ther., 69, 48 (2001); Nashan, B., et al.: Ther. Drug Monit., 24, 53 (2002); Venkata, S.P., et al.: PCT Int. Appl.ÂWOÂ2012066502ÂA1Â20120524. May 24, 2012