产品编号：B682025

产品规格：1g

产品价格：面议

---

产品详情

标准品编号:	B682025
名称:	tert-Butyl 4-Bromo-2-fluorobenzoate
别名:	2-Methylpropan-2-yl 4-bromo-2-fluorobenzoate; 4-Bromo-2-fluoro-benzoic Acid 1,1-Dimethylethyl Ester
CAS号:	889858-12-2
分子式:	C₁₁H₁₂BrFO₂
外观:	Clear Colourless Oil
分子量:	275.11
储存:	冰箱保存
溶解度:	Chloroform (Slightly), Methanol (Slightly)
类别:	Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	tert-Butyl 4-Bromo-2-fluorobenzoate is an intermediate of enzalutamide (M199800). Enzalutamide is an androgen-receptor antagonist that blocks androgens from binding to the androgen receptor and prevents nuclear translocation and co-activator recruitment of the ligand-receptor complex. MDV 3100 has also been shown to induce tumor cell apoptosis, and has no agonist activity. MDV 3100 is a candidate for the treatment of castration-resistant prostate cancer.
参考文献	Scher, H.I. et al.: Lancet, 375, 1437 (2010); Bellmunt, J. et al.: Ther. Adv. Med. Oncol., 2, 189 (2010); Ryan, C.J. et al.: J. Clin. Oncol., 29, 3651 (2011);