产品编号：B648220

产品规格：250mg

产品价格：面议

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产品详情

标准品编号:	B648220
名称:	Boc-3,5-dihydroxy-1-adamantyl-L-glycine
别名:	(S)-2-((tert-Butoxycarbonyl)amino)-2-((1r,3R,5S,7S)-3,5-dihydroxyadamantan-1-yl)acetic Acid; (αS)-α-[[(1,1-Dimethylethoxy)carbonyl]amino]-3,5-dihydroxytricyclo[3.3.1.13,7]decane-1-acetic Acid
CAS号:	681282-72-4
分子式:	C₁₇H₂₇NO₆
分子量:	341.4
类别:	Building Blocks; Chiral Molecules; Amino Acids;
应用:	Boc-3,5-dihydroxy-1-adamantyl-L-glycine is a reactant in the synthesis of Saxagliptin (S143500), a potent and selective reversible inhibitor of dipeptidyl peptidase-4, which is being developed for the treatment of type 2 diabetes. It is absorbed rapidly after oral administration and has a pharmacokinetic profile compatible with once daily dosing.
参考文献	Augeri, D.J., et. al.: J. Med. Chem., 48, 5025 (2005); Feng, J., et al.: J. Med. Chem., 50, 2297 (2007); Rosenstock, J., et al.: Diabetes Obes. Metab., 10, 376 (2008); Thomas, L., et al.: J. Pharmacol. Exp. Ther., 325, 175 (2008)