产品编号：B596300

产品规格：5mg

产品价格：面议

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产品详情

标准品编号:	B596300
名称:	BMS 599626
别名:	N-[4-[[1-[(3-Fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbamic Acid (3S)-3-Morpholinylmethyl Ester; AC 480;
CAS号:	714971-09-2
分子式:	C₂₇H₂₇FN₈O₃
分子量:	530.55
类别:	Research Tools;
应用:	It is a highly selective and potent inhibitor of HER1 and HER2 kinases and inhibits tumor cell proliferation through modulation of receptor signaling. BMS-599626 inhibits HER1/HER2 receptor heterodimerization and provides an additional mechanism of inhibiting tumors in which receptor coexpression and heterodimerization play a major role in driving tumor growth.
参考文献	Wiseman, L., et al.: Eur. J. Cancer, 29A, 2256 (1993), Wittman, M., et al.: J. Med. Chem., 48, 5639 (2005), Allen, G., et al.: Cancer Res., 67, 1155 (2007),