产品编号：B595912

产品规格：10mg

产品价格：面议

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产品详情

标准品编号:	B595912
名称:	BMS 181174-d4
别名:	(1aS,8R,8aR,8bS)-8-[[(Aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methyl-6-[[2-[(4-nitrophenyl)dithio]ethyl]amino]-azirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione-d4; [1aS-(1aα,8β,8aα,8bα)]-8-[[(Aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methyl-6-[[2-[(4-nitrophenyl)dithio]ethyl]amino]-azirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione-d4; BMY 25067-d4; N-7-(2-Nitrophenyldithio)ethyl)mitomycin C-d4
参考CAS:	95056-36-3 unlabelled
分子式:	C₂₃H₂₁D₄N₅O₇S₂
分子量:	551.63
类别:	Standards; Isotopic Labeled Analogues;
应用:	BMS 181174-d4 is labelled BMS 181174 (B595910), an analog of Mitomycin C (M371900) with activity against a range of tumour cell lines and xenografts, including MMC-resistant tumours. However, phase I clinical trials from Bristol-Myers Squibb demonstrated that the toxicity profile of BMS 181174 was no more favourable than that of mitomycin.
参考文献	Macaulay, V., et al.: Br. J. Cancer, 77, 2020 (1998); Xu, B., et al.: Cancer Res., 52, 6666 (1992); Kinoshita, S., et al.: J. Med. Chem., 14, 13 (1971), Beijnen, J.H., et al.: Anal. Profiles Drug Subs., 16, 361 (1986)