产品编号：B591755

产品规格：2.5mg

产品价格：面议

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产品详情

标准品编号:	B591755
名称:	B I09
别名:	7-(1,3-Dioxan-2-yl)-1,2,3,4-tetrahydro-8-hydroxy-5H-[1]benzopyrano[3,4-c]pyridin-5-one
CAS号:	1607803-67-7
分子式:	C₁₆H₁₇NO₅
分子量:	303.31
类别:	Research Tools; Molecular Biology; Enzyme Activators and Inhibitors;
应用:	B I09, is a novel chromenone-based covalent inhibitors of IIRE-1 RNase. It Inhibits IRE-1/XBP1 pathway, and thus growth of human chronic lymphocytic leukemia (CLL) cells in vitro and promotes CLL regression in a mouse model.
参考文献	Ranatunga. S. et al.: Journal of Medicinal Chemistry, Vol57,P: 4289-4301 (2014); Tang, Ch. et al.: Journal of Clinical Investigation, Vol 124, issue6, P:2585-2598 (2014);