产品编号：B591715

产品规格：5mg

产品价格：面议

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产品详情

标准品编号:	B591715
名称:	BI-847325
别名:	3-[3-[[[4-[(Dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-2-oxo-1H-indol-6-yl]-N-ethyl-2-propynamide; (Z)-3-(3-(((4-((Dimethylamino)methyl)phenyl)amino)(phenyl)methylene)-2-oxoindolin-6-yl)-N-ethylpropiolamide; BI 847325;
CAS号:	1207293-36-4
分子式:	C₂₉H₂₈N₄O₂
分子量:	464.56
类别:	Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	BI-847325 is a novel ATP-competitive MEK and Aurora kinase inhibitor. It can inhibit the growth of BRAF resistant melanoma cells through suppression of Mcl-1 and MEK expression in human melanoma cell lines and mouse xenograft model. The efficacy of BI-847325 was studied in patients with refractory solid tumors.
参考文献	Phadke, M., et al.: Mol. Cancer Ther., 14, 1354 (2015); Schoffski, P., et al.: Cancer Chemother. Pharmacol., 77, 99 (2016);