产品编号：B416125

产品规格：25g

产品价格：面议

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产品详情

标准品编号:	B416125
名称:	(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol
别名:	(αR)-α-methyl-3,5-bis(trifluoromethyl)-Benzenemethanol; (+)-(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol; (1R)-1-[3,5-Bis(Trifluoromethyl)phenyl]ethanol
CAS号:	127852-28-2
分子式:	C₁₀H₈F₆O
外观：	白色至白色固体
熔点:	46-53°C
分子量:	258.16
储存:	-20°C Freezer
溶解度:	Acetonitrile (Slightly), Chloroform (Slightly)
种类:	Building Blocks; Chiral Molecules;
应用:	(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol is an intermediate in the synthesis of Aprepitant (A729800), a novel selective neurokinin-1 (NK-1) receptor antagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1. Antiemetic.
文献	Vankawala, P.J., et. al.: Synthetic Comm., 37, 3439 (2007); Hale, J.J., et al.: J. Med. Chem., 41, 4607 (1998); Campos, D., et al.: J. Clin. Oncol., 19, 1759 (2001); Van Belle, S., et al.: Cancer, 94, 3032 (2002); Majumdar, A.K., et al.: J. Clin. Pharmacol., 46, 291 (2006)