产品编号：B415890
产品规格：250mg
产品价格：面议
| 标准品编号: | B415890 |
| 名称: | 4-[(1E,3S,5Z,8R/S,10S)-3,11-Bis-{[tert-butyl(dimethyl)silyl]oxy}-2,6,10-trimethyl-undeca-1,5-dienyl]-2-methyl-1,3-thiazole |
| 别名: | 4-[(1E,3S,5Z,10S)-3,11-Bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2,6,10-trimethyl-1,5-undecadien-1-yl]-2-methyl-thiazole; |
| CAS号: | 210690-85-0 |
| 分子式: | C₃₀H₅₇NO₂SSi₂ |
| 外观： | Colourless Oil |
| 分子量: | 552.02 |
| 溶解度: | Chloroform, Dichloromethane, Ethanol, Ethyl Acetate, Methanol, Toluene |
| 种类: | Standards; Chiral Molecules; |
| 应用: | An intermediate in the synthesis of Epothilones. Epothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to paclitaxel, and also are effective against paclitaxel-resistant tumours. Epothilone D is in phase I clinical testing of in patients with advanced solid tumours. Epothilone D is a cytotoxic macrolide that stabilises malignant cells' microtubules and arrests mitosis, a characteristic it shares with other epothilones. They bind to the same hepatic sites as does paclitaxel (Taxol) in a 1:1 stoichiometric ratio of a, b-tubulin heterodimers. |
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