产品编号：B415725
产品规格：1mg
产品价格：面议
| 标准品编号: | B415725 |
| 名称: | (3S,6R,7S,12Z,15S,16E)-3,7-Bis-{[tert-butyl(dimethyl)silyl]oxy}-15-hydroxy-4,4,6,8,12,16-hexamethyl-17-(2-methyl-1,3-thiazol-4-yl)-5-oxoheptadeca-12,16-dienoic Acid |
| 别名: | [3S-(3R*,6S*,7R*,8R*,12Z,15R*,16E)]-3,7-Bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-15-hydroxy-4,4,6,8,12,16-hexamethyl-17-(2-methyl-4-thiazolyl)-5-oxo-12,16-heptadecadienoic Acid; |
| CAS号: | 193146-26-8 |
| 分子式: | C₃₉H₇₁NO₆SSi₂ |
| 外观： | Oil |
| 分子量: | 738.22 |
| 溶解度: | Chloroform, Dichloromethane, Ethanol, Ethyl Acetate, Methanol, Toluene |
| 种类: | Standards; Chiral Molecules; |
| 应用: | An intermediate in the synthesis of Epothilones. Epothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to paclitaxel, and also are effective against paclitaxel-resistant tumours. Epothilone D is in phase I clinical testing of in patients with advanced solid tumours. Epothilone D is a cytotoxic macrolide that stabilises malignant cells' microtubules and arrests mitosis, a characteristic it shares with other epothilones. They bind to the same hepatic sites as does paclitaxel (Taxol) in a 1:1 stoichiometric ratio of a, b-tubulin heterodimers. |
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