产品编号：B384505

产品规格：5mg

产品价格：面议

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产品详情

标准品编号:	B384505
名称:	BI-78D3
别名:	4-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)-3-((5-nitrothiazol-2-yl)thio)-1H-1,2,4-triazol-5(4H)-one; 4-(2,3-Dihydro-1,4-benzodioxin-6-yl)-2,4-dihydro-5-[(5-nitro-2-thiazolyl)thio]-3H-1,2,4-triazol-3-one;
CAS号:	883065-90-5
分子式:	C₁₃H₉N₅O₅S₂
分子量:	379.37
类别:	Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	BI-78D3 is an inhibitor of JNK mediated signaling. Molecular docking studies on JNK inhibitors at allosteric JNK-JIP interaction site. JNK inhibition by BI-78D3 covalent binding to JNK at Cys163 or displacement of 2-mercapto-5-nitrothiazole, or addition of BI-78D3 oxidation product. A therapeutic target of the vascular JNK pathway which improves retinal endothelial vasodilator function during early diabetes.
文献	Kaoud, T. S., et al.: ACS Med. Chem., 3, 721 (2012); Rao, S. N., et al.: Current Science, 102, 1009 (2012); Borhani, D. W., et al.: Proc. Natl. Acad. Sci. U.S.A., 106, 18 (2009); Hein, T. W., et al.: Invest. Ophthalmol. Vis. Sci., 57, 4333 (2016)