产品编号：B289670

产品规格：250mg

产品价格：面议

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产品详情

标准品编号:	B289670
名称:	3’-O-Benzyl Sofosbuvir Desphosphate
别名:	1-((2R,3R,4R,5R)-4-(Benzyloxy)-3-fluoro-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
分子式:	C₁₇H₁₉FN₂O₅
分子量:	350.34
类别:	Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	3’-O-Benzyl Sofosbuvir Desphosphate may be a metabolite of Sofosbuvir (P839640), a prodrug that is metabolized to the active antiviral agent 2'-deoxy-2'-α-fluoro-β-C-methyluridine-5'-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.
文献	Lam, A.M.,et al.: Antimicrob. Agents. Chemotherapy., 56, 3359 (2012); Lam, A.M., et al.: J. Virol., 85, 12334 (2011); Sofia, M.J., et al.: J. Medn. Chem., 53, 7202 (2010);