产品编号：B208265

产品规格：100mg

产品价格：面议

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产品详情

标准品编号:	B208265
名称:	(3R,4S)-1-Benzoyl-4-phenyl-3-[(triethylsilyl)oxy]-2-azetidinone
别名:	(+)-cis-1-Benzoyl-3-triethylsilyloxy-4-phenyl-2-azetidinone; (3R,4S)-1-Benzoyl-4-phenyl-3-(triethylsiloxy)azetidin-2-one; (3R,4S)-1-Benzoyl-4-phenyl-3-(triethylsilyloxy)azetidin-2-one
CAS号:	149249-91-2
分子式:	C₂₂H₂₇NO₃Si
外观：	Transparent Oil
分子量:	381.54
溶解度:	Dichloromethane, Ether, Ethyl Acetate, Methanol
类别:	Standards; Chiral Molecules; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	(3R,4S)-1-Benzoyl-4-phenyl-3-[(triethylsilyl)oxy]-2-azetidinone is an intermedaite of 10-O-[(2R,3S)-3-(Benzoylamino)-2-hydroxy-3-phenylpropanoyl]-10-O-deacetylpaclitaxel (B207800), which is an impurity in the synthesis of Paclitaxel (P132500), an antineoplastic. Used in the study of structure and function of microtubles into tubulin. Paclitaxel is now used to treat patients with lung, ovarian, breast cancer, head and neck cancer, and advanced forms of Kaposi's sarcoma.
文献	Letourneau, P.C., et al.: J. Cell Biol., 98, 1355 (1984), Manfredi, J.J., et al.: Pharmacol. Ther., 25, 83 (1984), Danesi, R., et al.: Mol. Pharmacol., 47, 1106 (1995), Markman, M., et al.: Expert. Opin. Pharmacother., 3, 755 (2002), Stone, G.W., et al.: N. Engl. J. Med., 350, 221 (2004),