产品编号：B182695

产品规格：10mg

产品价格：面议

---

产品详情

标准品编号:	B182695
名称:	N-​[4-​[[(5S)​-​5-​(Benzoyloxy)​-​7-​chloro-​2,​3,​4,​5-​tetrahydro-​1H-​1-​benzazepin-​1-​yl]​carbonyl]​-​3-​methylphenyl]​-​2-​methylbenzamide
CAS号:	422571-07-1
分子式:	C₃₃H₂₉ClN₂O₄
外观：	白色固体
分子量:	553.05
溶解度:	Dichloromethane;
类别:	Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	N-​[4-​[[(5S)​-​5-​(Benzoyloxy)​-​7-​chloro-​2,​3,​4,​5-​tetrahydro-​1H-​1-​benzazepin-​1-​yl]​carbonyl]​-​3-​methylphenyl]​-​2-​methylbenzamide is an intermediate in the synthesis of (S)-(-)-Tolvaptan (T536645), which is an enantiomer of Tolvaptan. It is a selective, competitive arginine vasopressin V2 receptor antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH).
文献	Paterna, S., et al.: Eur. J. Heart Fail, 2, 305 (2000), Udelson, J., et al.: Circulation, 104, 2417 (2001), Goldsmith, S., et al.: J. Am. Coll Cardiol., 46, 1785 (2005), Schrier, R., et al.: N. Engl. J. Med., 355, 2099 (2006),