产品编号：B154170

产品规格：5mg

产品价格：面议

---

产品详情

标准品编号:	B154170
名称:	TBDMS 4-Hydroxy Carfilzomib
别名:	(S)-N-((S)-1-(((2R,4R)-1-((tert-Butyldimethylsilyl)oxy)-2-hydroxy-2,6-dimethyl-3-oxoheptan-4-yl)amino)-1-oxo-3-phenylpropan-2-yl)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamide
分子式:	C₄₆H₇₃N₅O₈Si
分子量:	852.19
类别:	Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	(S)-N-((S)-1-(((2R,4R)-1-((tert-Butyldimethylsilyl)oxy)-2-hydroxy-2,6-dimethyl-3-oxoheptan-4-yl)amino)-1-oxo-3-phenylpropan-2-yl)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamide is a byproduct in the synthesis of Carfilzomib (2R,4R)-Diol (C183525), which is a derivative of Carflizomib (C183460), a second-generation proteasome inhibitor that is used as a treatment in relapsed and refractory multiple myeloma.
文献	Fostier, K., et al.: Oncotargets. Therap., 5, 237 (2012); Geurink, P.P., et al.: J. Med. Chem., 56, 1262 (2013); McCormack, P.L., et al.: Drugs., 72, 2023 (2012);