产品编号：A965420
产品规格：2.5mg
产品价格：面议
| 标准品编号: | A965420 |
| 名称: | VIP(LA)485 |
| 别名: | N-(4-Fluorobenzyl)-2-((R)-5-(3-methylureido)-2',4'-dioxo-2,3-dihydrospiro[indene-1,5'-oxazolidin]-3'-yl)-N-((S)-1,1,1-trifluoropropan-2-yl)acetamide; A 485; (1R)-N-[(4-Fluorophenyl)methyl]-2,3-dihydro-5-[[(methylamino)carbonyl]amino]-2',4'-dioxo-N-[(1S)-2,2,2-trifluoro-1-methylethyl]spiro[1H-indene-1,5'-oxazolidine]-3'-acetamide |
| CAS号: | 1889279-16-6 |
| 分子式: | C₂₅H₂₄F₄N₄O₅ |
| 分子量: | 536.48 |
| 类别: | Standards; Enzyme Activators and Inhibitors; |
| 应用: | VIP(LA)485 is potent and selective p300/CREB-binding protein (CBP) HAT domain inhibitor (IC50 values are 2.6 and 9.8 nM for the CBP-bromodomain HAT-C/H3 (BHC) and p300-BHC domains, respectively). Displays > 1000-fold selectivity over closely related HATs. Suppresses proliferation in several hematological malignancies and AR+ prostate cancer cell lines in vitro. Inhibits tumor growth in a castration-resistant prostate cancer xenograft model. Orally bioavailable. |
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