产品编号：A795200
产品规格：5g
产品价格：面议
| 标准品编号: | A795200 |
| 名称: | rac 2-Azabicyclo[2.2.1]hept-5-en-3-one |
| 别名: | (+/-)-2-Azabicyclo[2.2.1]hept-5-en-3-one; (+/-)-Vince Lactam; Vince Lactam; Abacavir - In House Impurity; Abacavir Impurities |
| 杂质: | Abacavir - In House Impurity |
| CAS号: | 49805-30-3 |
| 分子式: | C₆H₇NO |
| 熔点: | 55-57°C |
| 分子量: | 109.13 |
| 储存: | 冰箱保存 |
| 类别: | Building Blocks; Miscellaneous; |
| 应用: | rac 2-Azabicyclo[2.2.1]hept-5-en-3-one (Abacavir - In House Impurity) is a useful reagent in the synthesis of carbocyclic sugar amines, carbanucleosides, and carbocyclic dinucleotide analogues (1). rac 2-Azabicyclo[2.2.1]hept-5-en-3-one is also an intermediate of Abacavir (A104990), a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively. |
| 文献 |
|
