产品编号：A794877

产品规格：100mg

产品价格：面议

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产品详情

标准品编号:	A794877
名称:	3-(Aminocarbonyl)-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-pyridinium Triflate
别名:	3-(Aminocarbonyl)-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-pyridinium 1,1,1-Trifluoromethanesulfonate; 3-(Aminocarbonyl)-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-pyridinium Salt with Trifluoromethanesulfonic Acid
CAS号:	774599-53-0
分子式:	C₁₇H₂₁N₂O₈⁺ • CF₃O₃S⁻
分子量:	381.3614907
类别:	Standards; Carbohydrates and Oligosaccharides;
应用:	3-(Aminocarbonyl)-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-pyridinium Triflate is an intermediate in synthesizing β-Nicotinamide Mononucleotide (N407765), a product of the extracellular Nicotinamide phosphoribosyltransferase (eNAMPT) reaction and a key NAD+ intermediate. It ameliorates glucose intolerance by restoring NAD+ levels in HFD-induced T2D mice. It also enhances hepatic insulin sensitivity and restores gene expression related to oxidative stress, inflammatory response, and circadian rhythm, partly through SIRT1 activation.
文献	Yoshino, J. et al.: Cell Metab., 14, 528 (2011); Caton, P.W. et al.: Diabetologia, 54, 3083 (2011); Formentini, L. et al.: BIochem. Pharmacol., 77, 1612 (2009);