产品编号：A777552

产品规格：2.5mg

产品价格：面议

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产品详情

标准品编号:	A777552
名称:	Artemisitene-d2
别名:	(3R,5aS,6R,8aS,12S,12aR)-Octahydro-3,6-dimethyl-9-methylene-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one-d2; (+)-Artemisitene-d2; Dehydroqinghaosu-d2
备用CAS:	未标记：101020-89-7
分子式:	C₁₅H₁₈D₂O₅
分子量:	282.33
类别:	Standards; Isotopic Labeled Analogues; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	Artemisitene-d2 is the labelled form of Artemisitene (A777550). Artemisitene, the oxidized form of Artemisinin (A777500), exists as a minor constituent in an American variant of Artemisia annua. Artemisinin precursors are the important basic substances for biosynthesis of Artemisinin, including Artemisinic acid, Artemisinin B, Artemisitene, etc. An antimalarial agent. Artemisitene-d2 is also an intermediate in the synthesis of Dihydro Artemisinin-d3 (D448362). The main labelled metabolite of Artemisinin, Arteether, Artemether, Artesunate. An active antimalarial metabolite.
文献	Li, Y., et al.: Curr. Med. Chem., 10, 2197 (2003); Marrero-Ponce, Y., et al.: Bioorg. Med. Chem., 13, 1293 (2005); McMichael, A., et al.: Lancet, 367, 859 (2006); e Vries, P., et al.: Drugs, 52, 818 (1996); Kamolrat, S., et al.: Antimicrob. Agents Chemother., 47, 3795 (2003); Mithwani, S., et al.: Br. J. Clin. Pharmacol., 57, 146 (2004)