产品编号：A771726
产品规格：10mg
产品价格：面议
| 标准品编号: | A771726 |
| 名称: | A 77-1726 |
| 别名: | N-(4-Trifluoromethylphenyl)-2-cyano-3-hydroxycrotonamide, 2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-beuteamide, LEF-M; Teriflunomide; Leflunomide EP Impurity B; Aubagio; A1726; (2Z)-2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide; Femorix; HMR 1726; SU 20 |
| 杂质: | Leflunomide EP Impurity B |
| CAS号: | 163451-81-8 |
| 备用CAS: | 108605-62-5 (Unspecified Stereochemistry)p |
| 分子式: | C₁₂H₉F₃N₂O₂ |
| 外观: | 白色固体 |
| 熔点: | 229-232°C |
| 分子量: | 270.21 |
| 储存: | Hygroscopic, -20°C Freezer, Under Inert Atmosphere |
| 溶解度: | DMSO, Methanol (Sparingly) |
| 类别: | Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites; |
| 应用: | A77 1726 (Leflunomide EP Impurity B) is the active metabolite of Leflunomide, a potent disease-modifying antirheumatic drug used in the treatment of rheumatoid arthritis. LEF-M interferes with dendritic cell function. The second Phase III study evaluating the efficacy of Genzyme’s teriflunomide therapy against relapsing forms of multiple sclerosis found the once-daily oral drug to be no less effective thanÂinjectable interferon beta 1a (Rebif®). |
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