产品编号：A634415
产品规格：
产品价格：面议
| 标准品编号: | A634415 |
| 名称: | (1R,4R)-rel-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol Hydrochloride |
| 别名: | Abacavir - In House Impurity; (1R,4R)-rel-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol Monohydrochloride; Abacavir EP Impurity D |
| 杂质: | Abacavir EP impurity D |
| CAS号: | 267668-71-3 |
| 备用CAS: | free base: 783292-37-5 |
| 分子式: | C₁₄H₁₉ClN₆O |
| 分子量: | 322.79 |
| 类别: | Standards; Pharmaceutical/API Drug Impurities/Metabolites; |
| 应用: | (1R,​4R)​-​rel-4-​[2-Amino-​6-​(cyclopropylamino)​-​9H-​purin-​9-​yl]​-​2-​cyclopentene-​1-​methanol Hydrochloride (Abacavir - In House Impurity) is an impurity of Abacavir (A105000). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively. |
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