产品编号：A618695

产品规格：25mg

产品价格：面议

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产品详情

标准品编号:	A618695
名称:	(R)-3-Amino-N-((R)-4-oxo-1-phenyl-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)butan-2-yl)-4-(2,4,5-trifluorophenyl)butanamide
分子式:	C₂₆H₂₆F₆N₆O₂
分子量:	568.51
类别:	Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	(R)-3-Amino-N-((R)-4-oxo-1-phenyl-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)butan-2-yl)-4-(2,4,5-trifluorophenyl)butanamide is an impurity of sitagliptin (S491000), which is a trizolopyrazine dipeptidyl peptidase IV inhibitor. Sitagliptin has recently been approved for the therapy of type II diabetes.
参考:	Kim, D., et al.: J. Med. Chem. 48, 141 (2005), Ahren, B., et al.: Eur. J. Pharmacol. 521 164 (2005), Bergman, A., et al: Clin. Ther. 28, 55 (2006)