产品编号：A614423

产品规格：50mg

产品价格：面议

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产品详情

标准品编号:	A614423
名称:	AMG 837 Hemicalcium Salt
别名:	(βS)-β-1-Propyn-1-yl-4-[[4'-(trifluoromethyl)[1,1'-biphenyl]-3-yl]methoxy]benzenepropanoic Acid Hemicalcium Salt; (βS)-β-1-Propyn-1-yl-4-[[4'-(trifluoromethyl)[1,1'-biphenyl]-3-yl]methoxy]-benzenepropanoic Acid Calcium Salt (2:1)
CAS号:	1291087-14-3
备用CAS:	Free Acid: 865231-46-5
分子式:	C₅₂H₄₀CaF₆O₆
分子量:	914.94
类别:	Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	AMG 837 Hemicalcium Salt is used in the synthetic preparation of a novel GPR40 receptor agonist, AMG 837 (A614410). GPR40 is a polyunsaturated fatty acid receptor that is involved with many systemic effects, which are beneficial for metabolic and inflammatory diseases. GPR40 has also been implicated as a target for treating obesity.
参考:	Walker, S.D.; et al.: Org. Process Res. Dev., 15, 570 (2011); Dragano, N. R. V., et al.: J Neuroinflammation. 14, 91 (2017); Houze, J. B., et al.: Bioorg Med Chem Lett. 22, 1267 (2012)