产品编号：A612145

产品规格：10mg

产品价格：面议

---

产品详情

标准品编号:	A612145
名称:	(2S)-2-Amino-4-methyl-1-[(2R)-2-methyloxiranyl]-1-pentanone Trifluoroacetate
别名:	(2S)-2-Amino-4-methyl-1-[(2R)-2-methyl-2-oxiranyl]-1-pentanone 2,2,2-Trifluoroacetate;
CAS号:	247068-85-5
备用CAS:	Free Base: 247068-84-4
分子式:	C₁₁H₁₈F₃NO₄
分子量:	285.26
类别:	Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	(2S)-2-Amino-4-methyl-1-[(2R)-2-methyloxiranyl]-1-pentanone Trifluoroacetate is an intermediate of Carfilzomib (C183460) which is a second-generation proteasome inhibitor that is used as a treatment in relapsed and refractory multiple myeloma.
参考:	Xiao, Q., et al.: Process for preparation of carfilzomib, China Patent 104710507, Jun 17, 2015; Fostier, K., et al.: Oncotargets. Therap., 5, 237 (2012); Geurink, P.P., et al.: J. Med. Chem., 56, 1262 (2013); McCormack, P.L., et al.: Drugs., 72, 2023 (2012)