产品编号：A604805

产品规格：500mg

产品价格：面议

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产品详情

标准品编号:	A604805
名称:	(4S)-4-Amino-2,6-dimethyl-1-hepten-3-one 2,2,2-Trifluoroacetate
CAS号:	1619233-32-7
备用CAS:	Free Base: 1469982-99-7
分子式:	C₁₁H₁₈F₃NO₃
分子量:	269.26
类别:	Building Blocks;
应用:	(4S)-4-Amino-2,6-dimethyl-1-hepten-3-one 2,2,2-Trifluoroacetate is a reagent used for carbonyls and epoxides as dual electrophiles in peptide-based proteasome inhibitors. This is also an impurity of carfilzomib (C183460), which is a second-generation proteasome inhibitor that is used as a treatment in relapsed and refractory multiple myeloma.
参考:	Xin, B., et al.: Org. Biomol. Chem., 12, 5710 (2014); Fostier, K., et al.: Oncotargets. Therap., 5, 237 (2012); Geurink, P.P., et al.: J. Med. Chem., 56, 1262 (2013); McCormack, P.L., et al.: Drugs., 72, 2023 (2012);