产品编号：A604390
产品规格：5mg
产品价格：面议
| 标准品编号: | A604390 |
| 名称: | cis-rac-4-(2-Amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol Hydrochloride |
| 别名: | (1R,4S)-rel-4-(2-Amino-6-chloro-9H-purin-9-yl)2-cyclopentene-1-methanol Hydrochloride; |
| CAS号: | 267668-74-6 |
| 备用CAS: | Free Base: 118237-87-9 |
| 分子式: | C₁₁H₁₂ClN₅O•HCl |
| 分子量: | 265.7 |
| 类别: | Standards; Pharmaceutical/API Drug Impurities/Metabolites; |
| 应用: | cis-rac-4-(2-Amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol Hydrochloride is an intermediate of Abacavir (A105000). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively. |
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