产品编号：A603935
产品规格：5g
产品价格：面议
| 标准品编号: | A603935 |
| 名称: | (1S,4R)-4-Amino-2-cyclopentene-1-methanol |
| 别名: | (1S-cis)-4-Amino-2-cyclopentene-1-methanol; |
| CAS号: | 136522-35-5 |
| 分子式: | C₆H₁₁NO |
| 状态： | 未标明外观 |
| 熔点： | 未标明外观 |
| 分子量: | 113.16 |
| 溶解性: | 未标明外观 |
| 类别: | Building Blocks; Miscellaneous; |
| 应用: | (1S,4R)-4-Amino-2-cyclopentene-1-methanol is a reagent for preparing cyclic ADP-carbocyclic-ribose analogs via Yoshikawa's phosphorylation and cyclocondensation (1). (1S,4R)-4-Amino-2-cyclopentene-1-methanol is also an intermediate for the synthesis of Abacavir (A105000). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (2). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (3). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively. |
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