产品编号：A603640
产品规格：1g
产品价格：面议
| 标准品编号: | A603640 |
| 名称: | (1S,4R)-cis-4-Amino-2-cyclopentene-1-methanol D-Tartrate |
| 别名: | (1S-cis)-4-Amino-2-cyclopentene-1-methanol D-Tartrate; (1S,4R)-cis-4-Amino-2-cyclopentene-1-methanol (2S,3S)-2,3-Dihydroxybutanedioate; Abacavir - In House Impurity; Abacavir Impurities |
| 杂质: | Abacavir - In House Impurity |
| CAS号: | 229177-52-0 |
| 备用CAS: | freebase: 136522-35-5 |
| 分子式: | C₁₀H₁₇NO₇ |
| 状态： | 白色至淡黄色固体 |
| 熔点： | >120°C (dec.) |
| 分子量: | 263.24 |
| 储存： | 冰箱保存 |
| 溶解性: | DMSO (Slightly), Methanol (Slightly, Heated, Sonicated) |
| 类别: | Building Blocks; Chiral Molecules; |
| 应用: | (1S,4R)-cis-4-Amino-2-cyclopentene-1-methanol D-Tartrate (Abacavir - In House Impurity) is an intermediate of Abacavir (A104990). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively. |
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