产品编号：A603383

产品规格：2.5mg

产品价格：面议

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产品详情

标准品编号:	A603383
名称:	5-Amino-2-chlorobenzotrifluoride N-Chloroacetyl N-Dehydroxy-2,3,4-tri-O-acetyl-D-glucuronic Acid Methyl Ester
别名:	(2R,3R,4S,5S,6S)-2-((4-Chloro-3-(trifluoromethyl)phenyl)(chlorocarbonyl)amino)-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl Triacetate
分子式:	C₂₁H₂₀Cl₂F₃NO₁₀
状态：	Yellow Solid
分子量:	574.29
类别:	Standards; Pharmaceutical/API Drug Impurities/Metabolites; Carbohydrates and Oligosaccharides;
应用:	5-Amino-2-chlorobenzotrifluoride N-Chloroacetyl N-Dehydroxy-2,3,4-tri-O-acetyl-D-glucuronic Acid Methyl Ester is an intermediate in the synthesis of Regorafenib N-β-D-Glucuronide Sodium Salt (R143320), which is a derivative of Regorafenib (R143000); a compound that inhibits PDGFR tyrosine kinase with IC50=83nM. Also useful for the treatment of inflammation and as an anti-proliferative agent.
参考:	Leuner, C., et al.: Eur. J. Pharm. Biopharm., 50, 47 (2000)