产品编号：A549652

产品规格：25mg

产品价格：面议

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产品详情

标准品编号:	A549652
名称:	17-(Allylamino-d5) Geldanamycin
别名:	17-Demethoxy-17-(2-propenylamino-d5)geldanamycin; 17-(Allylamino-d5)-17-demethoxygeldanamycin; 17-(Allylamino-d5)-17-desmethylgeldanamycin; 17-Demethoxy-17-(allylamino-d5)geldanamycin; 17AAG-d5; CP 127374-d5; KOS 953-d5; NSC 330507-d5; Tanespimycin-d5;
备用CAS:	未标记: 75747-14-7
分子式:	C₃₁H₃₈D₅N₃O₈
状态：	Dark Purple Solid
熔点：	161-163ËšC
分子量:	590.72
储存：	-20°C Freezer, Under Inert Atmosphere
溶解性:	DMSO, Methanol
类别:	Standards; Isotopic Labeled Analogues; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	Potent inhibitor of heat shock protein 90 (Hsp90). 17-AAG is a less toxic analog than Geldanamycin. It induces apoptosis and displays antitumor effects. 17-AAG inhibits the activity of oncogenic proteins such as N-ras, Ki-ras, c-Akt, and p185erB2.
参考:	Schnur, R.C., et al.: J. Med. Chem., 38, 3806 (1995), Nimmanapalli, R., et al.: Cancer Res., 61, 1799 (2001), Basso, A.D., et al.: Oncogene, 21, 1159 (2002),