产品编号：A425000
产品规格：10mg
产品价格：面议
| 标准品编号: | A425000 |
| 名称: | AG-490 |
| 别名: | 2-Cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-2-propenamide; Tyrphostin B 42; |
| CAS号: | 134036-52-5 |
| 分子式: | C₁₇H₁₄N₂O₃ |
| 状态： | Dark Yellow Solid |
| 熔点： | >213°C (dec.) |
| 分子量: | 294.3 |
| 储存： | -20°C Freezer |
| 溶解性: | Acetone, Chloroform, DMSO, Ethanol, Methanol |
| 类别: | Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites; |
| 应用: | A potent and specific inhibitor of the Jak-2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells which abundantly express JAK-2, AG-490 dose-dependently inhibited DNA synthesis, blocked cell growth and induced apoptosis. AG-490 does not significantly inhibit other kinases such as Lck, Lyn, Btk, Syk and Src. AG-490 is cell permeable and is active in vivo. |
| 危险品信息: | Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package |
| 参考: | |
