产品编号：A164385

产品规格：5mg

产品价格：面议

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产品详情

标准品编号:	A164385
名称:	(2aR,4S,4aS,6S,9S,11S,12S,12aR,12bS)-12b-Acetoxy-9-(((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-3-phenylpropanoyl)oxy)-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl Benzoate
分子式:	C₄₃H₅₃NO₁₄
分子量:	807.88
类别:	Standards; Chiral Molecules; Pharmaceutical/API Drug Impurities/Metabolites; Extracted;
应用:	(2aR,4S,4aS,6S,9S,11S,12S,12aR,12bS)-12b-Acetoxy-9-(((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-3-phenylpropanoyl)oxy)-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl Benzoate is a synthetic analogue of Paclitaxel (P132500), an antineoplastic of clinical interest for its activity in inhibiting microtubule disassembly and potency to treat lung, ovarian, breast cancer, and advanced forms of Kaposi's sarcoma.
参考:	Gueritte-Voegelein, F., et. al.: J. Med. Chem., 34, 992 (1991)Letourneau, P.C., et al.: J. Cell Biol., 98, 1355 (1984);Manfredi, J.J., et al.: Pharmacol. Ther., 25, 83 (1984);Danesi, R., et al.: Mol. Pharmacol., 47, 1106 (1995);Markman, M., et al.: Expert. Opin. Pharmacother., 3, 755 (2002);Stone, G.W., et al.: N. Engl. J. Med., 350, 221 (2004)