产品编号：A142800
产品规格：250mg
产品价格：面议
| 标准品编号: | A142800 |
| 名称: | 2-Acetamido-2-(4-octylphenethyl)malonic acid |
| 分子式: | C₂₁H₃₁NO₅ |
| 分子量: | 377.47 |
| 类别: | Standards; Pharmaceutical/API Drug Impurities/Metabolites; |
| 应用: | 2-Acetamido-2-(4-octylphenethyl)malonic acid is related to Fingolimod (F805000) which is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analogue of Sphingosine. Fingolimod is a novel immune modulator that prolongs allograft transplant survival in numberour models by inhibiting lymphocyte emigration from lymphoid organs. Fingolimod is reported to be phosphorylated by sphingosine kinase to FTY720-P, which has been shown to potently stimulate GTPgS binding activity in S1P-transfected CHO cells (EC50 = 210 pM, 4.9 nM, 4.3 nM, and 1 nM for S1P1, S1P3, S1P4 and S1P5, respectively). |
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