产品编号：A115606

产品规格：2.5mg

产品价格：面议

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产品详情

标准品编号:	A115606
名称:	Acalabrutinib-d3
别名:	4-[8-Amino-3-[(2S)-1-(1-oxo-2-butyn-1-yl)-2-pyrrolidinyl]imidazo[1,5-a]pyrazin-1-yl]-N-2-pyridinylbenzamide-d3;
备用CAS:	1420477-60-6
分子式:	C₂₆H₂₀D₃N₇O₂
分子量:	468.53
类别:	Standards; Isotopic Labeled Analogues; Molecular Biology; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	Acalabrutinib-d3 is a labeled analog of Acalabrutinib (A115605), which is an experimental anti-cancer drug and a selective Bruton's tyrosine kinase (BTK) inhibitor. This kinase transmits signals from B-cell Receptor (BCR), and thus any genetic BTK mutation causes B-Cell immunodeficiency. Therefore, BTK inhibitors targeting B-cell signaling has shown great promise for the treatment of chronic lymphocytic leukemia (CLL).
参考:	Byrd; et al. (2015). "Acalabrutinib (ACP-196) in Relapsed Chronic Lymphocytic Leukemia."; "AstraZeneca to buy Acerta for blood cancer drug". www.rsc.org. Chemistry World - Royal Society of Chemistry. Retrieved 24 December 2015.