产品编号：A105045
产品规格：10mg
产品价格：面议
| 标准品编号: | A105045 |
| 名称: | Abacavir Triphosphate TEA Salt |
| 别名: | P-[[(2S,4R)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopenten-1-yl]methyl]ester Triphosphate TEA Salt |
| 备用CAS: | Free acid: 137820-58-7 |
| 分子式: | C₁₄H₂₁N₆O₁₀P₃ • xC ₆H₁₅N |
| 状态： | 灰白色至浅褐色固体 |
| 熔点： | >104C (dec.) |
| 分子量: | 526.2710119 |
| 储存： | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| 溶解性: | Methanol (Slightly), Water (Slightly) |
| 类别: | Research Tools; Molecular Biology; Enzyme Activators and Inhibitors; |
| 应用: | Abacavir Triphosphate TEA Salt, is a metabolite of Abacavir. Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively. |
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