产品编号：A105025
产品规格：50mg
产品价格：面议
| 标准品编号: | A105025 |
| 名称: | rac-Abacavir Sulfate |
| 别名: | Abacavir Sulfate Racemic; (4-[2-Amino-6-(cyclopropylamino)-9H-purin-9yl]-2-cyclopentene-1-methanol Sulfate (2:1); |
| 备用CAS: | Racemic Mixture: 136470-79-6/188062-50-2 |
| 分子式: | C₂₈H₃₈N₁₂O₆S |
| 分子量: | 670.47 |
| 类别: | Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites; Anti-virals/Anti-retrovirals; |
| 应用: | rac-Abacavir Sulfate is a racemic mixture of ent-Abacavir (A105015) and Abacavir Sulfate (A105000). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively. |
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