产品编号：A105002
产品规格：10mg
产品价格：面议
| 标准品编号: | A105002 |
| 名称: | Abacavir-d4 |
| 别名: | (1S,4R)-4-[2-Amino-6-(cyclopropylamino-d4)-9H-purin-9-yl]-2-cyclopentene-1-methanol;(1S-cis)-4-[2-Amino-6-(cyclopropylamino-d4)-9H-purin-9-yl]-2-cyclopentene- 1-methanol; 1592U89-d4; ABC-d4; Abacavir Stable Isotope |
| CAS号: | 1217731-56-0 |
| 备用CAS: | 136470-78-5-未标记 |
| 分子式: | C₁₄H₁₄D₄N₆O |
| 状态： | 白色至Light Beige Solid |
| 熔点： | >70°C (dec.) |
| 分子量: | 290.36 |
| 储存： | Hygroscopic, -20˚C Freezer, Under Inert Atmosphere |
| 溶解性: | DMSO (Slightly), Methanol (Slightly) |
| 稳定性: | Very Hygroscopic |
| 类别: | Standards; Isotopic Labeled Analogues; Pharmaceutical/API Drug Impurities/Metabolites; |
| 应用: | Abacavir-d4 is deuterium labeled Abacavir (A104990). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively. |
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