产品编号：A105000
产品规格：50mg
产品价格：面议
| 标准品编号: | A105000 |
| 名称: | Abacavir Sulfate |
| 别名: | (1S,4R)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol Sulfate; Ziagen; Abacavir - In House Impurity; Abacavir Impurities; Abacavir Intermediates |
| 杂质: | Abacavir - In House Impurity |
| CAS号: | 188062-50-2 |
| 备用CAS: | free base: 136470-78-5 |
| 分子式: | C₂₈H₃₈N₁₂O₆S |
| 状态： | 白色至白色固体 |
| 熔点： | >205°C (dec.) |
| 分子量: | 670.74 |
| 储存： | -20°C Freezer, Under inert atmosphere |
| 溶解性: | Methanol (Slightly), Water (Slightly) |
| 类别: | Standards; Pharmaceutical/API Drug Impurities/Metabolites; |
| 应用: | Abacavir Sulfate (Abacavir - In House Impurity) is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively. |
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