产品编号：A104995
产品规格：10mg
产品价格：面议
| 标准品编号: | A104995 |
| 名称: | trans-Abacavir Dihydrochloride |
| 别名: | (1R,4R)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol Diydrochloride; |
| 备用CAS: | (HCl 1:1): 267668-71-3; 783292-37-5-free base |
| 分子式: | C₁₄H₂₀Cl₂N₆O |
| 状态： | Pale Yellow to Pale Orange Solid |
| 熔点： | >144°C (dec.) |
| 分子量: | 359.25 |
| 储存： | 冰箱保存 |
| 溶解性: | DMSO, Water (Slightly) |
| 类别: | Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites; |
| 应用: | trans-Abacavir Dihydrochloride is an impurity of Abacavir. Abacavir (A104990) is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively. |
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